Indonesia Conference Directory

Corresponding Author
Nurrahmi Umami

Institutions
Department of Midwifery, Graduate School, Hasanuddin University, Indonesia
Department of Pharmacy, Pharmacy Faculty, Hasanuddin University, Indonesia
Department of Obstetrics and Gynecology, Faculty of Medicine, Hasanuddin University, Indonesia

Abstract
Abstract Objective: This study aimed to analyze the impact on giving Ajwa date fruit (Phoenix dactylifera L.) in increasing a hemoglobin(Hb) level to a teenage girl. Methods: This study has used pre-experimental design, one group pretest, and posttest. The population was 119 teenage girl, and the sample was 35 persons chosen purposively. Samples were all female students around 15 – 18 years, Hb level >8 gr/dl to 12gr/dl, and already menarche. The used instruments were Hb test filling sheet and food recall 24 hours. The result was examined by using Paired T-test. Results: Result of this research shows that the average of hemoglobin level before the intervention was 10.786 gram/dL, and the average of hemoglobin level after intervention is 11.143 gr/dL. There is an increase of Hb level (0.357 gram/dL) after the intervention. Conclusion: Based on the result of this study, it can be concluded that there is an increase of Hb to teenage after the intervention of Ajwa the date fruit.

Keywords
Hemoglobin; Date Fruit; Phoenix dactylifera L.

Topic
Herbal medicine

Link: https://ifory.id/abstract/UrNKJgwd2Zap

Corresponding Author
Dyah Ratna Ayu Puspita Sari

Institutions
Faculty of Pharmacy, Hasanuddin University, Makassar, Indonesia

Abstract
Diabetes mellitus is a metabolic disease characterized by chronic hyperglycemia due to abnormal insulin secretion, insulin action or both. Breadfruit has been used in traditional medicine for diabetes mellitus. This study aims to see the effect of giving ethanol breadfruit leaf extract to pancreatic damage induced by alloxan-nicotinamide. Rats were induced with alloxan-nicotinamide and grouped into 4 groups, namely group I (normal) without treatment, group II (positive) given metformin 100 mg/kg body weight (BW), group III (negative) given Na CMC, group IV given breadfruit leaves extract 100 mg/kg BW, group V given breadfruit leaves extract 400 mg/kg BW. Treatment given for 14 days and histopathological examination of the pancreas. The results showed that group I pancreatic histopathology was not damaged, Group II suffered damage of 25% -75%, Group III with 25% damage, and group IV showed 50% and group V showed pancreatic damage from 0-25%. Breadfruit leaves extract 400 mg/kg BW has better activity to protect the pancreas and reduced the effect of pancreatic damage in rats.

Keywords
Diabetes mellitus, breadfruit leaves, alloxan, nicotinamide, pancreatic

Topic
Herbal medicine

Link: https://ifory.id/abstract/9ahgR3GP6ZHq

Corresponding Author
Feby Purnamasari

Institutions
a) Midwifery Section, Graduated School, Hasanuddin University, Indonesia
*risfahyulianty[at]unhas.ac.id
b) Department of Pharmacy, Hasanuddin University, Indonesia

Abstract
Objective : This study aimed to analyze the effectiveness of soursop leaf extract on IL-6 levels in mammals of Sprague Dawley mice induced by Staphylococcus aureus . Method: This study is a True Experiment which is a laboratory experiment, with the design of the Post-test Only Control Design Group . The study was divided into four treatment groups consisting of five rats induced by S. aureus 2 x 107 CFU / ml , 1 x 24 hours. Group I (negative control) who were only given Na. CMC 0.5%, Group II (Positive Control) with cefadroxil antibiotics 45 mg / kgBB, group III with soursop leaf extract 100 mg / KgBB, and group IV administering ethanol extract of soursop leaves in combination with cefadroxil antibiotics. Each group was treated twice in a day (12 hours ) for 5 days. Levels of IL-6 were measured on day 3 and day 6 after induction of S. aureus, tested by ELISA technique and analyzed by One Way Anova test and Paired Samples T test Results : N values of IL-6 levels in group III of 7 , 50 ± 1.74 pg/ml on day 3, and 4.51 ± 1.47 pg/ml on day 6. The results showed that there were differences in IL-6 levels in the group given the soursop leaf ethanol extract (ρ = 0.037 <0.05) . Conclusion: Ethanol extract of soursop leaves can be used as a complementary therapy for mastitis caused by the Staphylococcus aureus bacteria

Keywords
Soursop leaf extract, Interleukin-6 (IL-6), Staphylococcus aureus, Sprague dawley

Topic
Herbal medicine

Link: https://ifory.id/abstract/AwhGBNUmuFkT

Corresponding Author
Sitti Nurana

Institutions
Hasanuddin University

Abstract
Obhjective: This research aims to determine the effectiveness difference of Annona muricata leaf extract dose of 100mg/Kg BW (Bodi Weight) and the combination of cefadroxil 45mg/ kg BW and the annona muricata leaf extract 100mg/Kg BW on the 4th day and the 7th day to wards TNF-α level to Sprague Dawley Rat induced with S. aureus. Methods: This research was divided into four treatment groups which contain of five rats induced by S. Aureus 0,2 mlx108CFU, 1x24 hours, group I (negative control) which is only induced by Na. CMC 0,5%, group II (positive control) with Cefadroxil Antibiotics 9 mg, group III with annona muricata leaf extract 100mg/KgBW, and group IV with combination Cefadroxil Antibiotics and annona muricata leaf extract 100 mg/KgBW, every group got treatment twice in a day for five days. TNF-α grade was measured on 4th day and 7th day after the induction of S. aureus than tested by ELISA technique and analyzed by One Way Anova test and Independent sample T-Test. Result: On the 4th day is found the value of p> 0,05 the comparison between the control groups and each group. These indicate that there is no significant difference of the reduction of TNF-α level on the 4th day. On 7th day In the control group and the treatment control of combination of Antibiotics and Annona muricata Leaf Extract, it is found significant difference hith the p value of > 0,05 on the 7th day with average difference 43,26 ng/ml. Conclusion: Combination of Annona muricata leaf extract and Cefadroxil effective against TNF-α levels in Mammae female rat Sprague Dawley-induced Staphylococcus aureus on the 7th day

Keywords
Annona muricata leaf extract, TNF- α, S. aureus, Sprague dawley Rat

Topic
Herbal medicine

Link: https://ifory.id/abstract/WwDCuN4Y8y37

Corresponding Author
Nurrahmi Umami

Institutions
Conservative Dentistry Department, Faculty of Dentistry, Hasanuddin University, Makassar, Indonesia

Abstract
Abstract Objective: To determine the ability of brown algae (Sargassum sp) extract 15% in dissolving canal smear layer. Conservative Dentistry Department, Faculty of Dentistry, Hasanuddin University, Makassar, Indonesia Results: Root canals that were irrigated using brown algae (Sargassum sp) extract 15% showed a significant decrease of smear layer compared to other groups (p<0.05) either in 1/3 middle portion or 1/3 apical portion. Conclusion: Brown algae (Sargassum sp) extract 15% was more effective to clean smear layer on root canal wall compared to NaOCl 2.5% but did not show a significant difference compared to EDTA 17%.

Keywords
Brown algae (Sargassum sp) extract 15 %; EDTA 17%; NaOCl 2.5%; Saponin; Smear layer; Surfactant.

Topic
Herbal medicine

Link: https://ifory.id/abstract/hCAY7mFd38wz

Corresponding Author
Nurrahmi Umami

Institutions
Department Oral Biology, Faculty of Dentistry, Hasanuddin University, Makassar, Indonesia

Abstract
Abstract Objective: The aim of this study was to determine the effectiveness of topically administered corn silk extract to reduce inflammation degree in periodontitis. Methods: Material used in this research was 40 days old corn silk extract. Twelve male Wistar rats (Rattus novergicus) with the initial weight of 150 gram were used as experimental model animals. The rats were then divided into four groups with 3 rats each. The animals were induced with 5-O silk ligature wire for seven days. After that the silk ligatures were removed and each group were given treatments according to their group for seven days. Results: F3 shown the best anti-inflammation effect with mild inflammation in each sample (p<0.05). Whereas in F1 and F2 each sample had moderate inflammation (F1, F2: p>0.05). Conclusion: Topically administered corn silk extract (Zea mays. l.) are effective to reduce the degree of inflammation in periodontitis.

Keywords
Corn silk extract; Inflammation; Periodontitis

Topic
Herbal medicine

Link: https://ifory.id/abstract/TjedkF8Z69Jn

Corresponding Author
Ani Ani

Institutions
1Department Of Midwifery, Graduated School, Hasanuddin University, Indonesia
2Department Of Onkology, Doctor Faculty, Hasanuddin University, Indonesia
3Department Of Pharmacy , Pharmacy, Hasanuddin University, Indonesia
4Physiology Departement, Doctor Faculty, Hasanuddin University, Indonesia
5Doctor Department, Doctor Faculty, Hasanuddin University, Indonesia

Abstract
Objective: This study aimed to analyze the effectiveness of centella asiatica leaf extract on IL-6 levels in the mammals of Sprague dawley mice induced by Staphylococcus aureus. Method : Type of Research True-Experiment is a laboratory experiment, with the design of the Post-test Only Control Design Group. The study was divided into four treatment groups consisting of five rats induced by Staphylococcus aureus 2 x 107 CFU / ml, 1 x 24 hours. Group I (negative control) is only given Na. CMC 0.5%, Group II (Positive Control) was given Cefadroxil antibiotics 45 mg/kgBB, group III was given centella asiatica leaf extract 100 mg/KgBB, group IV was given centella asiatica leaf extract combined with antibiotic Cefadroxil. Each group was given treatment twice a day (12 hours) for 5 days. Levels of IL-6 were measured on day 4 and day 7 after induction of Staphylococcus aureus, tested by ELISA technique and analyzed by One Way Anova test and Paired Samples T test. Results: The value of IL-6 levels in group III was 5.32 ± 0.55 pg/ml on day 4, and 3.49 ± 1.26 pg/ml on day 7. The results showed that there were differences in IL-6 levels in the group given the centella asiatica leaf extract (ρ = 0,017 < 0,05). Conclusion: Pegagan leaf extract can suppress pro-inflammatory cytokines after administration of treatment on mammals of Sprague Dawley mice induced by Staphylococcus aureus.

Keywords
Centella asiatica extract, Interleukin-6 (IL-6), Staphylococcus aureus, Sprague dawley.

Topic
Herbal medicine

Link: https://ifory.id/abstract/Kw9QLR72Yjvc

Corresponding Author
ENNI SUKRIANI

Institutions
Hasanuddin University

Abstract
Ginger contains oleoresin and essential oils that can reduce the emesis of gravidarum in pregnancy. This research aims to determine the effect of giving ginger syrup on pregnant mothers to decrease the emesis gravidarum of the first trimester pregnant women. This study constituted quantitative research with quasi experiment. Design used was pretest-posttest. The samples in this research were 51 pregnant women divided into 3 groups, namely mothers who got ginger syrup, placebo, and motherrs who got B6. Implementation was carried out for 7 days. Data were analyzed using Chi Square,and Wilcoxon Test The results indicate the lowering of the frequency emesis gravidarum on the group given ginger syrup (p = 0,000), the group given placebo (p = 0.038), and the group given B6 (p = 0.003). The different mean value after 7 days of intervention are : Gingger syrup group (1.00 ± 0.00), Placebo group( 0.06 ± 0.01), and B6 group( 0.17 ± 0.1). The group given with ginger syrup is more effective to decrease the frequency of emesis gravidarum to the first trimester compared to B6 group and Placebo group.

Keywords
Ginger, Pregnant Women, Emesis Gravidarum

Topic
Herbal medicine

Link: https://ifory.id/abstract/tMgkQJEuDvCX

Corresponding Author
MELLIYANA NURDIN

Institutions
1Bagian Kebidanan, Sekolah Pascasarjana,Universitas Hasanuddin, Indonesia
2Bagian Farmasi, Fakultas Farmasi, Universitas Hasanuddin, Indonesia
3Bagian Bedah Onkologi, Fakultas Kedokteran, Universitas Hasanuddin, Indonesia

*risfahyulianty[at]unhas.ac.id

Abstract
Objective: This study aims to determine the effectiveness of Centella asiatica (L). Urban extraction TNF-α levels in female Sprague dawley rats induced by S. aureus. Methods: There were four treatment groups (each group consisted of five rats). Before treatment, S. aureus 0.2 mlx108 CFU was induced. Group I was only given 0.5% Na CMC, Cefadroxil group II 45 mg / kg WB, Group III Centella leaf extract 100 mg / Kg WB, and group IV combination Cefadroxil and Centella leaf extract. Each group was given treatment twice per 12 hours a day for 5 days. TNF-α levels were measured on day 3 and day 6 after induction of S. aureus tested by ELISA and analyzed by One Way ANOVA test and independent sample T test. Results: TNF-α level between groups did not have a significant on day 3 and differed significantly after day 6. On day 3, the control group had a higher TNF-α level of 25.13 pg/ml compared to the group given antibiotics and Centella asiatica. While when compared to the group given only Centella asiática the control group was more height of 17.1 pg /ml. On the 6th day this condition was changed, the biggest difference found in the group given Centella asiatica, in the control group had higher levels of TNF-α 72.34 pg / ml compared to the group receiving Centella asiática. Then, control group is higher than 66.46 pg/ml compared to those given antibiotics and Centella asiatica. Conclusion: C. asiatica leaf extract is effective in reducing TNF both given alone and given along with antibiotics. It is potential to be explored into alternative and complementary treatments in mastitis cases with human trials.

Keywords
Centella asiática L. Urban Leaf Extract, Mastitis, TNF-α, Sprague dawley

Topic
Herbal medicine

Link: https://ifory.id/abstract/GJCtfYKeDwb6

Corresponding Author
Nurrahmi Umami

Institutions
Midwifery Department, Graduated School, Hasanuddin University, Indonesia
Epidemiology Department, Public Health, Hasanuddin University, Indonesia
Chemistry Faculty, Hasanuddin University, Indonesia
Agriculture Department, Hasanuddin University, Indonesia
Medicine Faculty, Hasanuddin University, Indonesia

Abstract
Abstract Objective: This study aimed to assess the response of supplementation of honey and honey propolis to women who experience mild stress. Methods: The subjects of 30 people were divided into 3 groups; control, honey, and propolis honey every 10 people per group. All groups were given the same dose of 60 grams/day for 14 days. Measurements of glucocorticoid and cortisol hormones using Enzyme-Linked Immunosorbent Assay (ELISA) and the difference in cortisol hormone levels before and after the intervention were analyzed by a paired T-test. Results: Honey and propolis honey group decrease cortisol levels but none of the groups have significant changes. This is reciprocal with the changes in the hormone cortisol, the decrease in glucocorticoid hormone levels in the group given honey is the highest following propolis honey and the control group. However, changes in glucocorticoid hormones in the honey group were statistically significant. Conclusion: Our result confirmed that in women who experience mild stress, honey and honey propolis have the potential to reduce stress-related hormones, that is glucocorticoids and cortisol, this reduction does not have the potential to suppress the immune system.

Keywords
Stress; Women; Honey; Propolis; Cortisol Glucocorticoid

Topic
Herbal medicine

Link: https://ifory.id/abstract/c4LzUta2qdTW

Corresponding Author
Nurrahmi Umami

Institutions
Oral and Maxillofacial Radiology Department, Dentistry Faculty, Hasanuddin University, Makassar, Indonesia.

Abstract
Abstract Objective: This research was aimed to observe the hard and soft tissue lesion in the oral cavity assessed with the periapical and panoramic radiographic examination in Dental Hospital of Hasanuddin University. Methods: It was an observational descriptive study with cross-sectional design through periapical and panoramic data from April – May 2017. The results were presented in the distribution table and graphic. Results: To diagnose almost various oral cavity lesions, the dentist need to receipt a radiographic examination both intraoral and extraoral radiography. The most common hard tissue lesions that detected through periapical radiographic were caries 37.1%, pulp lesion 34.6% and periodontal lesion 17.9%. In panoramic radiographic data, the highest prevalence of tissue lesion was periodontal lesion and periapical abnormality 33.7% with the number of women was higher than men in the 12-25 year age group. Conclusion: The prevalence of hard and soft tissue lesion in the oral cavity was high.

Keywords
Hard Tissue Lesion; Oral Cavity; Periapical; Panoramic; Soft Tissue Lesion

Topic
Herbal medicine

Link: https://ifory.id/abstract/awhxNutJfHpP

Corresponding Author
Nurrahmi Umami

Institutions
Department of Dermatology and Venereology, Faculty of Medicine, Hasanuddin University, Makassar, Indonesia.
Department of Microbiology, Faculty of Medicine, Hasanuddin University, Makassar, Indonesia.
Faculty of Pharmacy, Hasanuddin University, Makassar, Indonesia.
Faculty of Public Health, Hasanuddin University, Makassar, Indonesia.

Abstract
Abstract: Objective: This study aims to observe the effect of mangosteen skin extract on BAX expression. Methods: This experimental study was done in 30 mice randomly assigned to groups receiving different treatments. The control group received Dimethyl-Benz(a)anthracene (DMBA), a potent carcinogen, induction while the treatment groups received mangosteen skin extract with 100, 200, and 400 ppm concentrations. The BAX level from each mouse was assessed using ELISA. Result: BAX level in the treatment group was higher than the control group, except at the dose of 100 ppm. BAX level in mice treated with 200 ppm and 400 ppm was higher than the control group with the 200 ppm group showing a higher level. Conclusion: Mangosteen skin extract increased BAX level in DMBA-induced mice.

Keywords
BAX; DMBA; Mangosteen skin extract

Topic
Herbal medicine

Link: https://ifory.id/abstract/djrmTtcfPH9F

Corresponding Author
Nurrahmi Umami

Institutions
Periodontology Department, Faculty of Dentistry, Hasanuddin University, Makassar, Indonesia
Microbiology Department, Molecular Biology and Immunology Laboratorium, Faculty of Medicine,
Hasanuddin University, Makassar, Indonesia
Pediatric Dentistry Department, Faculty of Dentistry, Hasanuddin University, Makassar, Indonesia

Abstract
Abstract Objective: To determine maximum inhibition of siwak extract against Aggregatibacter actinomycetemcomitans. Method: This study was an experimental laboratory with post-test only control group design. The study sample was Aggregatibacter actinomycetemcomitans in MHA medium. Total 24 samples were divided into 6 treatment groups, 5 groups of siwak-s extract with different concentration, 3.125%, 6.25%, 12.5%, 25%, 50% and 1 treatment group with DMSO control 5%. The inhibitory zone was measured after 48 hours incubation at 37 ° using calipers. Data analysis was performed with the Kruskal Wallis test. Results: The average diameter of inhibition zones at concentrations 3.125%, 6.25%, 12.5%, 25%, and 50% were 6.4 mm, 7.0 mm, 7.2 mm, 7.9 mm, and 8.6 mm, respectively. Conclusion: The maximum inhibition of siwak extract that can inhibit the growth of Aggregatibacter actinomycetemcomitans bacteria as one of the pathogenic bacteria that causes periodontal disease was siwak extract with a concentration of 50%

Keywords
Aggregatibacter actinomycetemcomitans; Maximum inhibitory test; Siwak-s extract

Topic
Herbal medicine

Link: https://ifory.id/abstract/XYxrj4vU9eKT

Corresponding Author
Nurrahmi Umami

Institutions
Midwifery Department, Graduate School, Hasanuddin University, Indonesia
Department of Pharmacy, Hasanuddin University, Indonesia

Abstract
Abstract Objective: This study aimed to analyse the Potential effectiveness effect Annona muricata L. extract as complementary therapy of interleukin-6 (IL-6) level of Sprague-Dawley rats induced by S. aureus. Method: It was a laboratory experiment, with a post-test only control group design. The group was divided into four treatment groups consisting of five rats induced by S. aureus 2 x 107 CFU/ ml, 1 x 24 hours; negative control (1st group) were only given CMC-Na 0.5 %, Positive Control (2nd group) given cefadroxil 45 mg/kg BW, 3rd group given Annona muricata L. extract 100 mg/kg BW, and 4th group given Annona muricata L. extract combined with cefadroxil. Each group was given treatment twice a day (12 hours) for five days. IL-6 levels were measured on the 3rd day (after induction S. aureus or before intervention) and 6th day (after intervention), tested by ELISA technique and data analysed by One Way Anova test and Paired Samples T-test. Results: Giving Annona muricata L. extract only or combined with cefadroxil could reduce levels of IL-6 significantly, when compared with cefadroxil, giving cefadroxil only did not have a significant effect even a decrease in IL-6 is very low, this is different if a combination of Annona muricata L. and cefadroxil. Conclusion: Ethanol extract of Annona muricata L. has the potential as a complementary therapy for mastitis caused by the bacterium S. aureus.

Keywords
Annona muricata L.; S.aureus; IL-6

Topic
Herbal medicine

Link: https://ifory.id/abstract/YnPRwFcWZk7p

Corresponding Author
Nurrahmi Umami

Institutions
Department of Biochemistry, Medicine Faculty, Hasanuddin University, Indonesia
Department of Midwifery, Medicine Faculty, Hasanuddin University, Indonesia
Research Institution and Community Service, Wuna Agricultural Science University, Indonesia

Abstract
Abstract Objective: This study aimed to examine whether honey and propolis Trigona are able to reduce level of leptin in central obesity human. Methods: It was a quasi-experimental study, population and sample were central obesity and normal weight as control. Sample size was 30 participants taken using purposive sampling. Results: Intervention as long as 14 days make an increased level of leptin as many as 97.076 Pg/ml in control group and decreasing respectively 171.803 Pg/ml and 245.293 Pg/ml in honey and propolis intervention group, both significant statistically. The dose of honey given was 105 mg/days divided into 3 packs, each pack contains 35 mg. The dose of propolis was 60 mg/days and divided into 3 capsules, each of it contains 20 mg. Intervention as long as 14 days and leptin levels examined using human ELISA Kit three times, that is before intervention, 7 days after intervention and 14 days after intervention. Conclusion: Honey and propolis Trigona has the ability to decrease leptin level of central obesity participants. These honey bee products are potential to be a dietary supplement for central obesity patients.

Keywords
Propolis; Honey; Trigona; Leptin

Topic
Herbal medicine

Link: https://ifory.id/abstract/8V6jfbkNdapc

Corresponding Author
Jumrah S

Institutions
a. Doctoral Program, Faculty of Medicine, Hasanuddin University
*jumrah.mega.rezky[at]gmail.com
b. Midwifery Departemen, Faculty of Nursing and Midwifery, Megarezky University
c. Midwife Proffesion, Faculty of Nursing and Midwifery, Megarezky University
d. Midwifery Departemen, Faculty of Nursing and Midwifery, Megarezky University

Abstract
Diabetes mellitus (DM) is one of kinds of degenerative disease that get increasing every years in countries in whole world. Main symptoms of diabetes mellitus are signified by increasing of blood glucose so that it is needed the effort to reduce it by natural ingredient. The increasing of diabetes mellitus risk to the menopouse women because of metabolic changes that happen when they are menopouse period. This research aimed to prove that natural ingredient of sappan wood decoction can reduce blood sugar level to diabetes mellitus suffers especially menopouse women who had high risk. This research used quantitative research method with pre post test design planning in one treatment group. It was obtained the result of suffers- blood glucose level before and after giving threatment (decoction of sappan wood) by using this method. The number of sample was 30 respondents (suffers- diabetes mellitus). Result of paired sample t test was obtained p = 0.005 < α = 0.05. it meant that Ho was rejected or there is effectivity decoction of sappan wood towards reducing blood glucose level to menopouse women with diabetes mellitus in 2018 of Makassar city.

Keywords
blood glucose level, decoction of sappan wood, menopouse women

Topic
Herbal medicine

Link: https://ifory.id/abstract/TdVkEqNncvh9

Corresponding Author
Mutmainah Arif

Institutions
1Graduated School, Hasanuddin University, Indonesia
2Departement of Biochemistry Faculty of Medicine, Hasanuddin University, Indonesia
*ikayustisia[at]gmail.com

Abstract
Objective: This study aims to see the development of tumor tissue in rats given the combination of ethanol extract of Moringa leaves (Moringa oleifera L.) and ethanol extract of papaya leaves (Carica papaya L.) as an alternative to increasing nutrition in slowing tumor tissue which will be used for further studies on phytotherapy as an alternative medicine for cancer. Methods: This study was conducted experimentally using a laboratory Complete Random Design (CRD) method. Results: The results show that there are different changes in body weight between groups for 12 weeks. However, based on the results of the one way ANOVA test, there is no significant differences between groups (p> 0.05). The appearance of tumor tissue was detected at week 7 in the comparison group (DMBA). Whereas in the positive control group and the combination extract group, the solid period began to be felt at the 10th week. Based on the results of histopathological tests in rat organs show that the growth of cancer tissue in all test animals in the treatment group given by DMBA. Conclusion: The combination from ethanol extract of Moringa leaves (Moringa oleifera L.) and ethanol extract of papaya leaves (Carica papaya L.) at a dose of 150 mg/kgBB has activity in slowing the formation of cancer tissue.

Keywords
Moringa leaves; papaya leaves; breast cancer; DMBA.

Topic
Herbal medicine

Link: https://ifory.id/abstract/kvZyn9MbXKrQ

Corresponding Author
Nurrahmi Umami

Institutions
Department of Orthodontics, Faculty of Dentistry, Hasanuddin University, Makassar, Indonesia

Abstract
Abstract Objective: To determine the effect of Binahong leaf extract in inhibiting the growth of Candida albicans in patients using removable orthodontic appliances. Method: Laboratory based experiment was conducted with the design of the Post-test Only Control Group Design involving 5 samples of removable orthodontic appliances which were swabbed to obtain Candida albicans, then each tested with binahong leaf extract concentrations of 10%, 30%, 50%, 70%, and the control group. The antifungal properties were measured through the diameter of inhibition zone formed. Results: Binahong leaf extract with a concentration of 10%, 30%, 50%, and 70% has the effect of inhibiting the growth of Candida albicans. Conclusion: Binahong leaf extract effects on inhibiting the growth of Candida albicans in patients using removable orthodontic appliances.

Keywords
Orthodontic appliances; Candida albicans; Binahong leaf extract; Flavonoid; Saponin.

Topic
Herbal medicine

Link: https://ifory.id/abstract/zZDcuGqE8PM4

Corresponding Author
JUSNIA JUSNIA

Institutions
¹Department of Midwifery, Graduate School, Hasanuddin University, Indonesia
²Department of Pharmacy, Pharmacy Faculty, Hasanuddin University, Indonesia
³Department of fisiology, Doctor Faculty, Hasanuddin University, Indonesia

Abstract
Objective: The research aims to determine the effectiviness of pegagan leave extrac5 on day 3 and 6 on the ability to suppress inflammation in Sprague Dawley female rats induced with S. aureus and to analyze the difference of IL-10 between group that was given antibiotics, pegagan leave extract and combination of both on day 3 and 6 after induction. Methods: This research laboratory experiment with Post-test Onl Control Group Design. The rats were divided into four groups, i.e. treatment group with Na CMC 0,5%, group with antibiotic cefadroxil 45 mg/kgBB, group with pegagan leave extract 100mg/kgBB, and group with antibiotic cefadroxil 45 mg/kgBB + pegagan leave extract 100mg/kgBB. All groups consisted of 5 rats induced with s.aureus 0,2 ml x 108 CFU (1X24 hours) and each group was given twice treatment per day (12 hours) for 5 days induction. Result: IL-10 level was measured on day 3 and 6 S. aureus with ELISA method. The results of measurement were compared between treatment groups and control group. The data were processed and analysed using One Way Anova test and T Test. The results showed that there was an increase in IL-10 level from day 3 to day 6 off all groups. However, there was no difference on IL-10 level between groups. Conclusion: pegagan leave extract is less effective to increase IL-10 level of mastitis rats.

Keywords
pegagan leave extract, IL-10 level, sprague dawley, staphlococcus aureus

Topic
Herbal medicine

Link: https://ifory.id/abstract/QmU9NDWEH3Zy

Corresponding Author
Reskiawati azis

Institutions
aDepartment of Midwifery, Graduate School, Hasanuddin University, Indonesia
bFaculty of Pharmacy, Hasanuddin University, Indonesia
cDepartment of Obstetrics and Gynecology, Faculty of Medicine, Hasanuddin University, Indonesia

Abstract
Objective:This research aimed to prove that the giving of dragon fruit extract (Hylocereus polyrhizus) can influence the reducing of pregnant white rat-s cholesterol level (Rattus norvegicus) Method:It was a laboratory study used 25 white rats. Animal group was divided into 5 groups, i.e., a negative control group (standard feed), a positive control group (simvastatin 0.18 mg), and three treatment groups (a dosage of dragon fruit 18 mg/200 gram of body weight (BW), 27 mg/200gram of body weight and 45 mg/200gram of body weight). All groups were inducted into the enormously-fat feed. The treatment was given for seven days. The examination wasused cholesterol checkup tool, i.e., Easy touch EGC. Result: The result of the research shows that dragon fruit extract could reduce the cholesterol level. The average cholesterol level reduction in a negative control group is 58.60 mg/dl, a positive control group is 82.20 mg/dl, a treatment group of dragon fruit with a dose of 18 mg/200 gram of body weight is 119.40mg/dl, dragon fruit with a dose of 27 mg/200 gram of body weight is 132.40 mg/dl, and a dragon fruit with a dose of 45 mg/200 gram of body weight is 161.20 mg/dl. All cholesterol levels were statistically significant Conclusion: Dragon fruit extract hasan impact on reducing cholesterol level to pregnant white rat (Rattus novergicus).

Keywords
Cholesterol;Hypercholesterolemia; Dragon fruit extract

Topic
Herbal medicine

Link: https://ifory.id/abstract/vrneNfPLh9BH